Artemisinin exerts a protective effect in the MPTP mouse model of Parkinson's disease by inhibiting microglial activation via the TLR4/Myd88/NF-KB pathway.

ABSTRACT:

Aims

We performed cell and animal experiments to explore the therapeutic effect of artemisinin on Parkinson's disease (PD) and the TLR4/Myd88 signaling pathway.

Methods

C57 mice were randomly divided into the blank, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced and artemisinin-treated groups. Clinical symptoms, the number of dopaminergic (DAergic) neurons in the substantia nigra, and microglial cell activation were compared among the three groups. Subsequently, BV-2 cell activation and TLR4/Myd88 pathway component expression were compared among the blank, MPP⁺ -treated, artemisinin-treated, and TLR4 activator-treated groups.

Results

Behavioral symptoms were improved, the number of DAergic neurons in the substantia nigra of the midbrain was inc

SUBMITTER: Lv J 

PROVIDER: S-EPMC10018080 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature