Brain structure and allelic associations in Alzheimer's disease.

ABSTRACT:

Background

Alzheimer's disease (AD), the most prevalent form of dementia, affects 6.5 million Americans and over 50 million people globally. Clinical, genetic, and phenotypic studies of dementia provide some insights of the observed progressive neurodegenerative processes, however, the mechanisms underlying AD onset remain enigmatic.

Aims

This paper examines late-onset dementia-related cognitive impairment utilizing neuroimaging-genetics biomarker associations.

Materials and methods

The participants, ages 65-85, included 266 healthy controls (HC), 572 volunteers with mild cognitive impairment (MCI), and 188 Alzheimer's disease (AD) patients. Genotype dosage data for AD-associated single nucleotide polymorphisms (SNPs) were extracted from the imputed ADNI genetics arch

SUBMITTER: Moon SW 

PROVIDER: S-EPMC10018103 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature