Dataset Information

The utility of diffusion-weighted imaging for differentiation of phyllodes tumor from fibroadenoma and breast cancer.

ABSTRACT:

Objective

To evaluate the utility of apparent diffusion coefficient (ADC) values for differentiating breast tumors.

Methods

The medical records of 17 patients with phyllodes tumor [PT; circular regions of interest (ROI-cs) n = 171], 74 patients with fibroadenomas (FAs; ROI-cs, n = 94), and 57 patients with breast cancers (BCs; ROI-cs, n = 104) confirmed by surgical pathology were retrospectively reviewed.

Results

There were significant differences between PTs, FAs, and BCs in ADCmean, ADCmax, and ADCmin values. The cutoff ADCmean for differentiating PTs from FAs was 1.435 × 10^-3 mm²/s, PTs from BCs was 1.100 × 10^-3 mm²/s, and FAs from BCs was 0.925 × 10^-3 mm²/s. There were significant differences between benign PTs, borderline PTs, and malignant PTs in ADCmean, ADCmax, and ADCmin values. The cutoff ADCmean for differentiating benign PTs from borderline PTs was 1.215 × 10^-3 mm²/s, and borderline PTs from malignant PTs was 1.665 × 10^-3 mm²/s.

Conclusion

DWI provides quantitative information that can help distinguish breast tumors.

SUBMITTER: Fang J

PROVIDER: S-EPMC10018141 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

The utility of diffusion-weighted imaging for differentiation of phyllodes tumor from fibroadenoma and breast cancer.

Fang Jinzhi J Zhang Yuzhong Y Li Ruifeng R Liang Lanlan L Yu Juan J Hu Ziqi Z Zhou Lingling L Liu Renwei R

Frontiers in oncology 20230302

<h4>Objective</h4>To evaluate the utility of apparent diffusion coefficient (ADC) values for differentiating breast tumors.<h4>Methods</h4>The medical records of 17 patients with phyllodes tumor [PT; circular regions of interest (ROI-cs) n = 171], 74 patients with fibroadenomas (FAs; ROI-cs, n = 94), and 57 patients with breast cancers (BCs; ROI-cs, n = 104) confirmed by surgical pathology were retrospectively reviewed.<h4>Results</h4>There were significant differences between PTs, FAs, and BCs ...[more]

PMID: 36937381

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Project description:The European Society of Breast Radiology (EUSOBI) established an International Breast DWI working group. The working group consists of clinical breast MRI experts, MRI physicists, and representatives from large vendors of MRI equipment, invited based upon proven expertise in breast MRI and/or in particular breast DWI, representing 25 sites from 16 countries. The aims of the working group are (a) to promote the use of breast DWI into clinical practice by issuing consensus statements and initiate collaborative research where appropriate; (b) to define necessary standards and provide practical guidance for clinical application of breast DWI; (c) to develop a standardized and translatable multisite multivendor quality assurance protocol, especially for multisite research studies; (d) to find consensus on optimal methods for image processing/analysis, visualization, and interpretation; and (e) to work collaboratively with system vendors to improve breast DWI sequences. First consensus recommendations, presented in this paper, include acquisition parameters for standard breast DWI sequences including specifications of b values, fat saturation, spatial resolution, and repetition and echo times. To describe lesions in an objective way, levels of diffusion restriction/hindrance in the breast have been defined based on the published literature on breast DWI. The use of a small ROI placed on the darkest part of the lesion on the ADC map, avoiding necrotic, noisy or non-enhancing lesion voxels is currently recommended. The working group emphasizes the need for standardization and quality assurance before ADC thresholds are applied. The working group encourages further research in advanced diffusion techniques and tailored DWI strategies for specific indications. Key Points • The working group considers breast DWI an essential part of a multiparametric breast MRI protocol and encourages its use. • Basic requirements for routine clinical application of breast DWI are provided, including recommendations on b values, fat saturation, spatial resolution, and other sequence parameters. • Diffusion levels in breast lesions are defined based on meta-analysis data and methods to obtain a reliable ADC value are detailed.

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Dataset Information

The utility of diffusion-weighted imaging for differentiation of phyllodes tumor from fibroadenoma and breast cancer.

Objective

Methods

Results

Conclusion

Publications

The utility of diffusion-weighted imaging for differentiation of phyllodes tumor from fibroadenoma and breast cancer.

Similar Datasets

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