Preterm birth leads to a decreased number of differentiated podocytes and accelerated podocyte differentiation.

ABSTRACT: Preterm birth was previously identified as a high-risk factor for the long-term development of chronic kidney disease. However, the detailed pattern of podocyte (PD) changes caused by preterm birth and the potential mechanism underlying this process have not been well clarified. In present study, a rat model of preterm birth was established by delivery of pups 2 days early and podometric methods were applied to identify the changes in PDs number caused by preterm birth. In addition, single-cell RNA sequencing (scRNA-seq) and subsequent bioinformatic analysis were performed in the preterm rat kidney to explore the possible mechanism caused by preterm birth. As results, when the kidney completely finished nephrogenesis at the age of 3 weeks, a reduction in the total number of differentiated

SUBMITTER: Zhang L 

PROVIDER: S-EPMC10018169 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature