De-escalation of Therapy in Patients with Quiescent Inflammatory Bowel Disease.

ABSTRACT: Inflammatory bowel disease is a chronic disease of unknown origin that requires long-term treatment. The optical duration of maintenance treatment once remission has been achieved remains unclear. When discussing a de-escalation strategy, not only the likelihood of relapse but also, the outcome of retreatment for relapse after de-escalation should be considered. Previous evidence has demonstrated controversial results for risk factors for relapse after de-escalation due to the various definitions of remission and relapse. In fact, endoscopic or histologic remission has been suggested as a treatment target; however, it might not always be indicative of a successful drug withdrawal. For better risk stratification of relapse after de-escalation, it may be necessary to evaluate both the curren

SUBMITTER: Miyatani Y 

PROVIDER: S-EPMC10018304 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature