Bupropion Slow Release vs Placebo With Adaptive Incentives for Cocaine Use Disorder in Persons Receiving Methadone for Opioid Use Disorder: A Randomized Clinical Trial.

ABSTRACT:

Importance

Opioid-stimulant co-use is a common problem with few evidence-based treatments.

Objective

To examine bupropion slow release (SR) enhancement of a tailored abstinence incentive program for stimulant use in persons with opioid use disorder.

Design, setting, and participants

This 26-week, double-blind, placebo-controlled randomized clinical trial with a 4-week follow-up period was conducted at 4 methadone treatment programs in Baltimore, Maryland. Included participants were persons receiving methadone for the treatment of opioid use disorder with past 3-month cocaine use and current cocaine use disorder between March 2015 and September 2019. Data were analyzed from November 2020 through August 2022.

Interventions

A 6-week incentive induction period with

SUBMITTER: Ware OD 

PROVIDER: S-EPMC10018324 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature