Epigenetic and chromosomal features drive transposon insertion in Drosophila melanogaster.

ABSTRACT: Transposons are mobile genetic elements prevalent in the genomes of most species. The distribution of transposons within a genome reflects the actions of two opposing processes: initial insertion site selection, and selective pressure from the host. By analyzing whole-genome sequencing data from transposon-activated Drosophila melanogaster, we identified 43 316 de novo and 237 germline insertions from four long-terminal-repeat (LTR) transposons, one LINE transposon (I-element), and one DNA transposon (P-element). We found that all transposon types favored insertion into promoters de novo, but otherwise displayed distinct insertion patterns. De novo and germline P-element insertions preferred replication origins, often landing in a narrow region around transcription start sites and in regio

SUBMITTER: Cao J 

PROVIDER: S-EPMC10018349 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature