Key transcription factors influence the epigenetic landscape to regulate retinal cell differentiation.

ABSTRACT: How the diverse neural cell types emerge from multipotent neural progenitor cells during central nervous system development remains poorly understood. Recent scRNA-seq studies have delineated the developmental trajectories of individual neural cell types in many neural systems including the neural retina. Further understanding of the formation of neural cell diversity requires knowledge about how the epigenetic landscape shifts along individual cell lineages and how key transcription factors regulate these changes. In this study, we dissect the changes in the epigenetic landscape during early retinal cell differentiation by scATAC-seq and identify globally the enhancers, enriched motifs, and potential interacting transcription factors underlying the cell state/type specific gene expression

SUBMITTER: Ge Y 

PROVIDER: S-EPMC10018358 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature