Novel bionic inspired nanosystem construction for precise delivery of mRNA.

ABSTRACT: The intracellular delivery of messenger (m)RNA holds great potential for the discovery and development of vaccines and therapeutics. Yet, in many applications, a major obstacle to clinical translation of mRNA therapy is the lack of efficient strategy to precisely deliver RNA sequence to liver tissues and cells. In this study, we synthesized virus-like mesoporous silica (V-SiO₂) nanoparticles for effectively deliver the therapeutic RNA. Then, the cationic polymer polyethylenimine (PEI) was included for the further silica surface modification (V-SiO₂-P). Negatively charged mRNA motifs were successfully linked on the surface of V-SiO₂ through electrostatic interactions with PEI (m@V-SiO₂-P). Finally, the supported lipid bilayer (LB) was completely w

SUBMITTER: Yang T 

PROVIDER: S-EPMC10018395 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature