Synthesis and Photoreactivity of 7-Nitroindoline-S-thiocarbamates.

ABSTRACT: The photolytic properties of N-acyl-7-nitroindolines make these compounds attractive as photocleavable protecting groups and "caged" compounds for the light-induced release ("uncaging") of biologically active compounds and as acylating reagents under neutral conditions. However, the synthesis of N-acyl-7-nitroindolines usually requires multiple steps, and the direct acylation of 7-nitroindolines can be quite challenging. 7-Nitroindolines with other types of N-carbonyl-containing groups may also be photoreactive and could potentially be better accessible. Here we demonstrate the short and efficient synthesis of 5-bromo-7-nitroindoline-S-thiocarbamates, a new class of photoreactive compounds, and the study of some of their photochemical and photophysical propertie

SUBMITTER: Baily PT 

PROVIDER: S-EPMC10018502 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature