Intrinsic disorder in the open reading frame 2 of hepatitis E virus: a protein with multiple functions beyond viral capsid.

ABSTRACT:

Background

Hepatitis E virus (HEV) is the cause of a liver disease hepatitis E. The translation product of HEV ORF2 has recently been demonstrated as a protein involved in multiple functions besides performing its major role of a viral capsid. As intrinsically disordered regions (IDRs) are linked to various essential roles in the virus's life cycle, we analyzed the disorder pattern distribution of the retrieved ORF2 protein sequences by employing different online predictors. Our findings might provide some clues on the disorder-based functions of ORF2 protein that possibly help us in understanding its behavior other than as a HEV capsid protein.

Results

The modeled three dimensional (3D) structures of ORF2 showed the predominance of random coils or unstructured regions in ad

SUBMITTER: Shafat Z 

PROVIDER: S-EPMC10018590 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature