Total synthesis of bi-magnolignan.

ABSTRACT: Bi-magnolignan, isolated from the leaves of Magnolia officinalis, has shown excellent physiological activity against tumor cells. An efficient strategy for the first total synthesis of bi-magnolignan is reported. The bi-dibenzofuran skeleton was constructed via functional group interconversions of commercially available materials 1,2,4-trimethoxybenzene and 4-allylanisole. Then, the dibenzofuran skeleton was afforded by subsequent Suzuki coupling and intramolecular dehydration. The total synthesis of natural product was accomplished through FeCl₃ catalyzed oxidative coupling.

SUBMITTER: Lu SY 

PROVIDER: S-EPMC10018648 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature