Evaluation of MRI-only based online adaptive radiotherapy of abdominal region on MR-linac.

ABSTRACT:

Purpose

A hybrid magnetic resonance linear accelerator (MRL) can perform magnetic resonance imaging (MRI) with high soft-tissue contrast to be used for online adaptive radiotherapy (oART). To obtain electron densities needed for the oART dose calculation, a computed tomography (CT) is often deformably registered to MRI. Our aim was to evaluate an MRI-only based synthetic CT (sCT) generation as an alternative to the deformed CT (dCT)-based oART in the abdominal region.

Methods

The study data consisted of 57 patients who were treated on a 0.35 T MRL system mainly for abdominal tumors. Simulation MRI-CT pairs of 43 patients were used for training and validation of a prototype convolutional neural network sCT-generation algorithm, based on HighRes3DNet, for the abdominal region.

SUBMITTER: Nousiainen K 

PROVIDER: S-EPMC10018672 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature