Bifunctional Blockade: A Novel Immunotherapy Approach for Cervical Cancer.
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ABSTRACT:
SUBMITTER: Miller KM
PROVIDER: S-EPMC10018812 | biostudies-literature | 2022 Dec
REPOSITORIES: biostudies-literature
Publications
Bifunctional Blockade: A Novel Immunotherapy Approach for Cervical Cancer.
Miller Kathryn M KM Friedman Claire F CF
Clinical cancer research : an official journal of the American Association for Cancer Research 20221201 24
SHR-1701, a bispecific fusion protein directed against PD-L1 and TGFβ, demonstrates promising clinical activity in advanced/recurrent cervical cancer. A recent study serves as a proof of principle that the TGFβ pathway may be successfully targeted, and that bispecific antibodies offer a novel therapeutic approach to do so. See related article by Feng et al., p. 5297. ...[more]
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