Alleviating the hypoxic tumor microenvironment with MnO₂-coated CeO₂ nanoplatform for magnetic resonance imaging guided radiotherapy.

ABSTRACT:

Background

Radiotherapy is a commonly used tool in clinical practice to treat solid tumors. However, due to the unique microenvironment inside the tumor, such as high levels of GSH, overexpressed H₂O₂ and hypoxia, these factors can seriously affect the effectiveness of radiotherapy.

Results

Therefore, to further improve the efficiency of radiotherapy, a core-shell nanocomposite CeO₂-MnO₂ is designed as a novel radiosensitizer that can modulate the tumor microenvironment (TME) and thus improve the efficacy of radiation therapy. CeO₂-MnO₂ can act as a radiosensitizer to enhance X-ray absorption at the tumor site while triggering the response behavior associated with the tumor microenvironment. According to in vi

SUBMITTER: Pi F 

PROVIDER: S-EPMC10018832 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature