The emergence of an imported variant of dengue virus serotype 2 in the Jazan region, southwestern Saudi Arabia.

ABSTRACT:

Background

Dengue virus (DENV) infection is a global economic and public health concern, particularly in tropical and subtropical countries where it is endemic. Saudi Arabia has seen an increase in DENV infections, especially in the western and southwestern regions. This study aims to investigate the genetic variants of DENV-2 that were circulating during a serious outbreak in Jazan region in 2019.

Methods

A total of 482 serum samples collected during 2019 from Jazan region were tested with reverse transcription-polymerase chain reaction (RT-PCR) to detect and classify DENV; positive samples underwent sequencing and bioinformatics analyses.

Results

Out of 294 positive samples, type-specific RT-PCR identified 58.8% as DENV-2 but could not identify 41.2%. Based on seque

SUBMITTER: Dafalla O 

PROVIDER: S-EPMC10018863 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature