Fecal microbiota from MRL/lpr mice exacerbates pristane-induced lupus.

ABSTRACT:

Background

The roles of gut microbiota in the pathogenesis of SLE have been receiving much attention during recent years. However, it remains unknown how fecal microbiota transplantation (FMT) and microbial metabolites affect immune responses and lupus progression.

Methods

We transferred fecal microbiota from MRL/lpr (Lpr) mice and MRL/Mpj (Mpj) mice or PBS to pristane-induced lupus mice and observed disease development. We also screened gut microbiota and metabolite spectrums of pristane-induced lupus mice with FMT via 16S rRNA sequencing, metagenomic sequencing, and metabolomics, followed by correlation analysis.

Results

FMT from MRL/lpr mice promoted the pathogenesis of pristane-induced lupus and affected immune cell profiles in the intestine, particularly the plas

SUBMITTER: Yi X 

PROVIDER: S-EPMC10018936 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature