The role of the desmosomal protein desmocollin 2 in tumour progression in triple negative breast cancer patients.

ABSTRACT:

Background

The disruption of epithelial features represents a critical step during breast cancer spread. In this context, the dysregulation of desmosomal proteins has been associated with malignant progression and metastasis formation. Curiously, both tumour suppressive and pro-metastatic roles have been attributed to desmosomal structures in different cancer entities. In the present study, we describe the pro-metastatic role of the desmosomal protein desmocollin 2 (DSC2) in breast cancer.

Methods

We analysed the prognostic role of DSC2 at mRNA and protein level using microarray data, western blot analysis and immunohistochemistry. Functional consequences of DSC2 overexpression and DSC2 knock down were investigated in the triple negative breast cancer (TNBC) cell line MDA-MB

SUBMITTER: Reimer F 

PROVIDER: S-EPMC10018948 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature