Activated FGFR3 suppresses bone regeneration and bone mineralization in an ovariectomized mouse model.

ABSTRACT:

Background

Postmenopausal osteoporosis is a widespread health concern due to its prevalence among older adults and an associated high risk of fracture. The downregulation of bone regeneration delays fracture healing. Activated fibroblast growth factor receptor 3 (FGFR3) accelerates bone regeneration at juvenile age and downregulates bone mineralization at all ages. However, the impact of FGFR3 signaling on bone regeneration and bone mineralization post-menopause is still unknown. This study aimed to evaluate the impact of FGFR3 signaling on bone regeneration and bone mineralization during menopause by developing a distraction osteogenesis (DO) mouse model after ovariectomy (OVX) using transgenic mice with activated FGFR3 driven by Col2a1 promoter (Fgfr3 mice).

Methods

The OV

SUBMITTER: Kawashima I 

PROVIDER: S-EPMC10018961 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature