Image-based modeling of vascular organization to evaluate anti-angiogenic therapy.

ABSTRACT: In tumor therapy anti-angiogenic approaches have the potential to increase the efficacy of a wide variety of subsequently or co-administered agents, possibly by improving or normalizing the defective tumor vasculature. Successful implementation of the concept of vascular normalization under anti-angiogenic therapy, however, mandates a detailed understanding of key characteristics and a respective scoring metric that defines an improved vasculature and thus a successful attempt. Here, we show that beyond commonly used parameters such as vessel patency and maturation, anti-angiogenic approaches largely benefit if the complex vascular network with its vessel interconnections is both qualitatively and quantitatively assessed. To gain such deeper insight the organization of vascular networks, w

SUBMITTER: Ascheid D 

PROVIDER: S-EPMC10018970 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature