Different outcomes following parathyroidectomy in patients with uremic tumoral calcinosis: two case reports.

ABSTRACT:

Background

Uremic tumoral calcinosis (UTC) is a rare complication in hemodialysis patients, whose mechanism remains incompletely understood. We report two cases with UTC who experienced completely different patterns of regression following parathyroidectomy, although there were no significant differences in serum calcium levels, parathyroid hormone, or phosphorus production between the two patients.

Case presentation

Case 1 had a substantial improvement in soft tissue calcification. However, in Case 2, one calcified mass was partially absorbed, while the others were aggravated with severe microvascular calcification and subcutaneous extravascular calcification. Whole-exome sequencing data revealed five mutation sites associated with atherosclerosis.

Conclusion

The dif

SUBMITTER: Li J 

PROVIDER: S-EPMC10018971 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature