Delivery route considerations for designing antigen-specific biomaterial strategies to combat autoimmunity.

ABSTRACT: Disease modifying drugs and biologics used to treat autoimmune diseases, although promising, are non-curative. As the field moves towards development of new approaches to treat autoimmune disease, antigen-specific therapies immunotherapies (ASITs) have emerged. Despite clinical approval of ASITs for allergies, clinical trials using soluble ASITs for autoimmunity have been largely unsuccessful. A major effort to address this shortcoming is the use of biomaterials to harness the features unique to specific delivery routes. This review focuses on biomaterials being developed for delivery route-specific strategies to induce antigen-specific responses in autoimmune diseases such as multiple sclerosis, type 1 diabetes, rheumatoid arthritis, and celiac disease. We first discuss the delivery strat

SUBMITTER: Ackun-Farmmer MA 

PROVIDER: S-EPMC10019031 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature