Harnessing natural killer cells for cancer immunotherapy: dispatching the first responders.

ABSTRACT: Natural killer (NK) cells have crucial roles in the innate immunosurveillance of cancer and viral infections. They are 'first responders' that can spontaneously recognize abnormal cells in the body, rapidly eliminate them through focused cytotoxicity mechanisms and potently produce pro-inflammatory cytokines and chemokines that recruit and activate other immune cells to initiate an adaptive response. From the initial discovery of the diverse cell surface receptors on NK cells to the characterization of regulatory events that control their function, our understanding of the basic biology of NK cells has improved dramatically in the past three decades. This advanced knowledge has revealed increased mechanistic complexity, which has opened the doors to the development of a plethora of excitin

SUBMITTER: Maskalenko NA 

PROVIDER: S-EPMC10019065 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature