Ontology highlight
ABSTRACT:
SUBMITTER: Gao L
PROVIDER: S-EPMC10019085 | biostudies-literature | 2023 Feb
REPOSITORIES: biostudies-literature
Gao Linfeng L Lam Kwok-Ho KH Liu Shun S Przykopanski Adina A Lübke Johanna J Qi Ruifeng R Krüger Maren M Nowakowska Maria B MB Selby Katja K Douillard François P FP Dorner Martin B MB Perry Kay K Lindström Miia M Dorner Brigitte G BG Rummel Andreas A Jin Rongsheng R
FEBS letters 20230127 4
Botulinum neurotoxins (BoNTs) are among the most lethal toxins known to humans, comprising seven established serotypes termed BoNT/A-G encoded in two types of gene clusters (ha and orfX) in BoNT-producing clostridia. The ha cluster encodes four non-toxic neurotoxin-associated proteins (NAPs) that assemble with BoNTs to protect and enhance their oral toxicity. However, the structure and function of the orfX-type NAPs remain largely unknown. Here, we report the crystal structures for OrfX1, OrfX2, ...[more]