Improved Aerosolization Stability of Inhalable Tobramycin Powder Formulation by Co-Spray Drying with Colistin.

ABSTRACT:

Purpose

Tobramycin shows synergistic antibacterial activity with colistin and can reduce the toxic effects of colistin. The purpose of this study is to prepare pulmonary powder formulations containing both colistin and tobramycin and to assess their in vitro aerosol performance and storage stability.

Methods

The dry powder formulations were manufactured using a lab-scale spray dryer. In vitro aerosol performance was measured using a Next Generation Impactor. The storage stability of the dry powder formulations was measured at 22°C and two relative humidity levels - 20 and 55%. Colistin composition on the particle surface was measured using X-ray photoelectron spectroscopy.

Results

Two combination formulations, with 1:1 and 1:5 molar ratios of colistin and tobramycin,

SUBMITTER: Pathak V 

PROVIDER: S-EPMC10019100 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature