Distinct tumor-infiltrating lymphocyte landscapes are associated with clinical outcomes in localized non-small-cell lung cancer.

ABSTRACT:

Background

Despite the importance of tumor-infiltrating T lymphocytes (TILs) in cancer biology, the relationship between TIL phenotypes and their prognostic relevance for localized non-small-cell lung cancer (NSCLC) has not been well established.

Patients and methods

Fresh tumor and normal adjacent tissue was prospectively collected from 150 patients with localized NSCLC. Tissue was comprehensively characterized by high-dimensional flow cytometry of TILs integrated with immunogenomic data from multiplex immunofluorescence, T-cell receptor sequencing, exome sequencing, RNA sequencing, targeted proteomics, and clinicopathologic features.

Results

While neither the magnitude of TIL infiltration nor specific TIL subsets were significantly prognostic alone, the integration

SUBMITTER: Federico L 

PROVIDER: S-EPMC10019222 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature