Antiviral Activity of trans-Hexenoic Acid against Coxsackievirus B and Enterovirus A71.

ABSTRACT: Enterovirus infections are life-threatening viral infections which occur mainly among children and are possible causes of viral outbreak. Until now, treatment and management of infections caused by members of the genus Enterovirus largely depended on supportive care, and no antiviral medications are currently approved for the treatment of most of these infections. The urgency of discovering new therapeutic options for the treatment of enterovirus infection is increasing. In the present study, we identified that trans-2-hexenoic acid (THA), a natural product from a dietary source, possesses antiviral activity against coxsackievirus B (CVB) and enterovirus A71 (EV-A71) in a dose-dependent manner. We found that THA possesses antiviral activity at 50% effective concentrations (EC

SUBMITTER: Olasunkanmi OI 

PROVIDER: S-EPMC10019289 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature