Dexamphetamine widens temporal and spatial binding windows in healthy participants.

ABSTRACT:

Background

The pathophysiology of psychosis is complex, but a better understanding of stimulus binding windows (BWs) could help to improve our knowledge base. Previous studies have shown that dopamine release is associated with psychosis and widened BWs. We can probe BW mechanisms using drugs of specific interest to psychosis. Therefore, we were interested in understanding how manipulation of the dopamine or catecholamine systems affect psychosis and BWs. We aimed to investigate the effect of dexamphetamine, as a dopamine-releasing stimulant, on the BWs in a unimodal illusion: the tactile funneling illusion (TFI).

Methods

We conducted a randomized, double-blind, counterbalanced placebo-controlled crossover study to investigate funnelling and errors of localization. We admini

SUBMITTER: Kassim FM 

PROVIDER: S-EPMC10019325 | biostudies-literature | 2023 Mar-Apr

REPOSITORIES: biostudies-literature