Macromolecular Solute Transport in Supramolecular Hydrogels Spanning Dynamic to Quasi-Static States.

ABSTRACT: Hydrogels prepared from supramolecular cross-linking motifs are appealing for use as biomaterials and drug delivery technologies. The inclusion of macromolecules (e.g., protein therapeutics) in these materials is relevant to many of their intended uses. However, the impact of dynamic network cross-linking on macromolecule diffusion must be better understood. Here, hydrogel networks with identical topology but disparate cross-link dynamics are explored. These materials are prepared from cross-linking with host-guest complexes of the cucurbit[7]uril (CB[7]) macrocycle and two guests of different affinity. Rheology confirms differences in bulk material dynamics arising from differences in cross-link thermodynamics. Fluorescence recovery after photobleaching (FRAP) provides insight into macrom

SUBMITTER: Braegelman AS 

PROVIDER: S-EPMC10019485 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature