Boosting compromised SARS-CoV-2-specific immunity with mRNA vaccination in liver transplant recipients.

ABSTRACT:

Background & aims

Liver transplant recipients (LTRs) demonstrate a reduced response to COVID-19 mRNA vaccination; however, a detailed understanding of the interplay between humoral and cellular immunity, especially after a third (and fourth) vaccine dose, is lacking.

Methods

We longitudinally compared the humoral, as well as CD4+ and CD8+ T-cell, responses between LTRs (n = 24) and healthy controls (n = 19) after three (LTRs: n = 9 to 16; healthy controls: n = 9 to 14 per experiment) to four (LTRs: n = 4; healthy controls: n = 4) vaccine doses, including in-depth phenotypical and functional characterization.

Results

Compared to healthy controls, development of high antibody titers required a third vaccine dose in most LTRs, while spike-specific CD8+ T cells with robus

SUBMITTER: Luxenburger H 

PROVIDER: S-EPMC10019593 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature