Epidemiology, management and outcomes of Cryptococcus gattii infections: A 22-year cohort.

ABSTRACT:

Background

Cryptococcus gattii is a globally endemic pathogen causing disease in apparently immune-competent hosts. We describe a 22-year cohort study from Australia's Northern Territory to evaluate trends in epidemiology and management, and outcome predictors.

Methods

A retrospective cohort study of all C. gattii infections at the northern Australian referral hospital 1996-2018 was conducted. Cases were defined as confirmed (culture-positive) or probable. Demographic, clinical and outcome data were extracted from medical records.

Results

45 individuals with C. gattii infection were included: 44 Aboriginal Australians; 35 with confirmed infection; none HIV positive out of 38 tested. Multifocal disease (pulmonary and central nervous system) occurred in 20/45 (44%). Nin

SUBMITTER: O'Hern JA 

PROVIDER: S-EPMC10019644 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature