Potential causal association between leisure sedentary behaviors, physical activity and musculoskeletal health: A Mendelian randomization study.

ABSTRACT:

Background

Increasing evidence shows that leisure sedentary behaviors (LSB) and physical activity (PA) are associated with various musculoskeletal disorders. However, the causality between LSB/PA and musculoskeletal health remained unknown. In this study, we aimed to evaluate the causal relationships between LSB/PA and lower back pain (LBP), intervertebral disc disorder (IVDD), rheumatoid arthritis (RA), and bone mineral density (BMD) by using a two-sample Mendelian randomization method.

Methods

The exposure data were obtained from large-scale genome-wide association studies (GWAS), including the PA dataset (self-reported PA, n  =  377,234; accelerometer-assessed PA, n  = 91,084) and LSB dataset (n  =  422,218). The outcome data were derived from the FinnGen LBP dataset (n 

SUBMITTER: Zhao X 

PROVIDER: S-EPMC10019723 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature