Tumor senescence leads to poor survival and therapeutic resistance in human breast cancer.

ABSTRACT:

Background

Breast cancer (BRCA) is the most common malignant tumor that seriously threatens the health of women worldwide. Senescence has been suggested as a pivotal player in the onset and progression of tumors as well as the process of treatment resistance. However, the role of senescence in BRCA remains unelucidated.

Methods

The clinical and transcriptomic data of 2994 patients with BRCA were obtained from The Cancer Genome Atlas and the METABRIC databases. Consensus clustering revealed senescence-associated subtypes of BRCA patients. Functional enrichment analysis explored biological effect of senescence. We then applied weighted gene co-expression network analysis (WGCNA) and LASSO regression to construct a senescence scoring model, Sindex. Survival analysis validated t

SUBMITTER: Zhai J 

PROVIDER: S-EPMC10019818 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature