Cognition and BDNF levels in prediabetes and diabetes: A mediation analysis of a cross-sectional study.

ABSTRACT:

Aim

Clinical and epidemiological studies suggest links between dementias and Type 2 diabetes (T2DM). The underlying mechanisms of diabetes-related cognitive impairment are largely unknown. This study aims to investigate the role of BDNF in cognitive impairment in prediabetes and T2DM.

Methods

The study included 68 patients with prediabetes (preDM), 96 patients with T2DM, and 65 healthy controls. The cognitive function of the patients was evaluated with the Montreal Cognitive Assessment (MoCA) test and serum BDNF levels were measured by Elisa. The MoCA scores and BDNF levels were compared between diabetes groups after adjusting for age, gender, and education using ANCOVA. The role of BDNF in the diabetes-related cognitive impairment was investigated through mediation analysis

SUBMITTER: Sumbul-Sekerci B 

PROVIDER: S-EPMC10019820 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature