Megakaryocytes respond during sepsis and display innate immune cell behaviors.

ABSTRACT: Megakaryocytes (MKs) are precursors to platelets, the second most abundant cells in the peripheral circulation. However, while platelets are known to participate in immune responses and play significant functions during infections, the role of MKs within the immune system remains largely unexplored. Histological studies of sepsis patients identified increased nucleated CD61⁺ cells (MKs) in the lungs, and CD61⁺ staining (likely platelets within microthrombi) in the kidneys, which correlated with the development of organ dysfunction. Detailed imaging cytometry of peripheral blood from patients with sepsis found significantly higher MK counts, which we predict would likely be misclassified by automated hematology analyzers as leukocytes. Utilizing in vitro techniq

SUBMITTER: Frydman GH 

PROVIDER: S-EPMC10019826 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature