The entorhinal-DG/CA3 pathway in the medial temporal lobe retains visual working memory of a simple surface feature.

ABSTRACT: Classic models consider working memory (WM) and long-term memory as distinct mental faculties that are supported by different neural mechanisms. Yet, there are significant parallels in the computation that both types of memory require. For instance, the representation of precise item-specific memory requires the separation of overlapping neural representations of similar information. This computation has been referred to as pattern separation, which can be mediated by the entorhinal-DG/CA3 pathway of the medial temporal lobe (MTL) in service of long-term episodic memory. However, although recent evidence has suggested that the MTL is involved in WM, the extent to which the entorhinal-DG/CA3 pathway supports precise item-specific WM has remained elusive. Here, we combine an established orie

SUBMITTER: Xie W 

PROVIDER: S-EPMC10019891 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature