KCNK9 mediates the inhibitory effects of genistein on hepatic metastasis from colon cancer.

ABSTRACT:

Objective

The tyrosine-protein kinase inhibitor, genistein, can inhibit cell malignant transformation and has an antitumor effect on various types of cancer. It has been shown that both genistein and KNCK9 can inhibit colon cancer. This research aimed to investigate the suppressive effects of genistein on colon cancer cells and the association between the application of genistein and KCNK9 expression level.

Methods

The Cancer Genome Atlas (TCGA) database was used to study the correlation between the KCNK9 expression level and the prognosis of colon cancer patients. HT29 and SW480 colon cancer cell lines were cultured to examine the inhibitory effects of KCNK9 and genistein on colon cancer in vitro, and a mouse model of colon cancer with liver metastasis was established to ve

SUBMITTER: Cheng Y 

PROVIDER: S-EPMC10019991 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature