Impact of treatment intensity on infectious complications in patients with acute myeloid leukemia.

ABSTRACT:

Background

Infectious complications reflect a major challenge in the treatment of patients with acute myeloid leukemia (AML). Both induction chemotherapy and epigenetic treatment with hypomethylating agents (HMA) are associated with severe infections, while neutropenia represents a common risk factor. Here, 220 consecutive and newly diagnosed AML patients were analyzed with respect to infectious complications dependent on treatment intensity and antifungal prophylaxis applied to these patients.

Patients and methods

We retrospectively analyzed 220 patients with newly diagnosed AML at a tertiary care hospital between August 2016 and December 2020. The median age of AML patients undergoing induction chemotherapy (n = 102) was 61 years (25-76 years). Patients receiving palliativ

SUBMITTER: Tober R 

PROVIDER: S-EPMC10020242 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature