Heterogeneous vascular response after implantation of bare nitinol self-expanding stents in the swine femoropopliteal artery.

ABSTRACT:

Background

Mechanism of femoropopliteal in-stent restenosis has been underappreciated.

Aim

The aim of this animal study was to elucidate vascular response after femoropopliteal bare nitinol self-expanding stents (SESs) implantation.

Methods

Misago, Smart Flex, or Innova stent was randomly implanted in 36 swine femoropopliteal arteries. At week 4, quantitative vessel analysis (QVA) was performed on 36 legs, of which 18 underwent histological evaluation after angiography. The remaining 18 legs underwent QVA and histological evaluation at week 13.

Results

Fibrin deposition was excessive at week 4. Internal elastic lamina (IEL) progressively enlarged over time, and vessel injury developed from mild level at week 4 to moderate level at week 13. Vessel inflammatory r

SUBMITTER: Kawarada O 

PROVIDER: S-EPMC10020252 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature