Retinal pathological features and proteome signatures of Alzheimer's disease.

ABSTRACT: Alzheimer's disease (AD) pathologies were discovered in the accessible neurosensory retina. However, their exact nature and topographical distribution, particularly in the early stages of functional impairment, and how they relate to disease progression in the brain remain largely unknown. To better understand the pathological features of AD in the retina, we conducted an extensive histopathological and biochemical investigation of postmortem retina and brain tissues from 86 human donors. Quantitative examination of superior and inferior temporal retinas from mild cognitive impairment (MCI) and AD patients compared to those with normal cognition (NC) revealed significant increases in amyloid β-protein (Aβ₄₂) forms and novel intraneuronal Aβ oligomers (AβOi), which were closely a

SUBMITTER: Koronyo Y 

PROVIDER: S-EPMC10020290 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature