IL-10-providing B cells govern pro-inflammatory activity of macrophages and microglia in CNS autoimmunity.

ABSTRACT: B cells contribute to chronic inflammatory conditions as source of antibody-secreting plasma cells and as antigen-presenting cells activating T cells, making anti-CD20-mediated B cell depletion a widely used therapeutic option. B cells or B cell subsets may, however, exert regulatory effects, while to date, the immunological and/or clinical impact of these observations remained unclear. We found that in multiple sclerosis (MS) patients, B cells contain regulatory features and that their removal enhanced activity of monocytes. Using a co-culture system, we identified B cell-provided interleukin (IL)-10 as key factor in controlling pro-inflammatory activity of peripheral myeloid cells as well as microglia. Depleting B cells via anti-CD20 in a mouse model of MS unleashed the activity of myelo

SUBMITTER: Geladaris A 

PROVIDER: S-EPMC10020302 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature