Undifferentiated pleomorphic sarcoma of the breast with neoplastic fever: case report and genomic characterization.

ABSTRACT:

Purpose

Primary breast sarcomas are extraordinary rare, in particular undifferentiated pleomorphic sarcoma (UPS). UPS with neoplastic fever (UPS-NF) of the breast has not been reported yet. Here, we present an extended UPS-NF of the breast including its comprehensive molecular workup.

Methods

A 58-year-old female presented with general malaise, fever spikes, weight loss, and a massively swollen left breast. C-reactive protein and blood leucocytes were significantly increased. However, repeated blood cultures and smears were all sterile. Histopathology of the abscess-forming tumor revealed an undifferentiated malignancy with numerous of tumor giant cells as well as spindle-shaped cells with nuclear pleomorphism and hyperchromasia. Immunohistochemistry demonstrated partial, pa

SUBMITTER: Gambichler T 

PROVIDER: S-EPMC10020307 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature