Laboratory variation in the grading of dysplasia of duodenal adenomas in familial adenomatous polyposis patients.

ABSTRACT: To prevent duodenal and ampullary cancer in familial adenomatous polyposis (FAP) patients, a diagnosis of high grade dysplasia (HGD) plays an important role in the clinical management. Previous research showed that FAP patients are both over- and undertreated after a misdiagnosis of HGD, indicating unwarranted variation. We aimed to investigate the laboratory variation in dysplasia grading of duodenal adenomas and explore possible explanations for this variation. We included data from all Dutch pathology laboratories between 1991 and 2020 by retrieving histology reports from upper endoscopy specimens of FAP patients from the Dutch nationwide pathology databank (PALGA). Laboratory variation was investigated by comparing standardized proportions of HGD. To describe the degree of variation be

SUBMITTER: Soons E 

PROVIDER: S-EPMC10020317 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature