Association between brain structures and migraine: A bidirectional Mendelian randomization study.

ABSTRACT:

Background

Accumulating evidence of clinical and neuroimaging studies indicated that migraine is related to brain structural alterations. However, it is still not clear whether the associations of brain structural alterations with migraine are likely to be causal, or could be explained by reverse causality confounding.

Methods

We carried on a bidirectional Mendelian randomization analysis in order to identify the causal relationship between brain structures and migraine risk. Summary-level data and independent variants used as instruments came from large genome-wide association studies of total surface area and average thickness of cortex (33,992 participants), gray matter volume (8,428 participants), white matter hyperintensities (50,970 participants), hippocampal volume (3

SUBMITTER: Guo X 

PROVIDER: S-EPMC10020331 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature