Serum metabolites as early detection markers of non-muscle invasive bladder cancer in Chinese patients

ABSTRACT:

Background

Biomarkers of different stages and grades of bladder cancer (BC) are important in clinical work. The objective of our study was to investigate new biomarkers of early-stage BC with liquid chromatography-high resolution mass spectrometry (LC-HRMS) using serum samples.

Methods

A total of 215 cases were included in our study, including 109 healthy adults as the control group and 106 non-muscle invasive bladder cancer (NMIBC) patients as the NMIBC group. Serum samples were collected from BC patients in the early stage, called NMIBC, and healthy people before surgery. We used LC-HRMS to distinguish the NMIBC group from the control group and the low-grade NMIBC group from the control group.

Results

An apparent difference between the NMIBC group and the contr

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC10020364 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature