Integrated whole-genome gene expression analysis reveals an atlas of dynamic immune landscapes after myocardial infarction.

ABSTRACT:

Introduction

Myocardial infarction (MI) is a deadly medical condition leading to irreversible damage to the inflicted cardiac tissue. Elevated inflammatory response marks the severity of MI and is associated with the development of heart failure (HF), a long-term adverse outcome of MI. However, the efficacy of anti-inflammatory therapies for MI remains controversial. Deciphering the dynamic transcriptional signatures in peripheral blood mononuclear cells (PBMCs) is a viable and translatable route to better understand post-MI inflammation, which may help guide post-MI anti-inflammatory treatments.

Methods

In this work, integrated whole-genome gene expression analysis was performed to explore dynamic immune landscapes associated with MI.

Results

GSEA and GSVA showed tha

SUBMITTER: Wang Y 

PROVIDER: S-EPMC10020602 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature