Dataset Information

Association between thyroid cancer and cardiovascular disease: A meta-analysis.

ABSTRACT:

Objective

To determine the association between thyroid cancer and coronary artery disease, atrial fibrillation, cerebrovascular disease, and cardiovascular disease mortality.

Methods

The PubMed, Embase, and Cochrane Library databases were searched for eligible studies from inception to September 22, 2022. Keywords included "thyroid cancer", "atrial fibrillation", "coronary artery disease", "cerebrovascular disease", and "mortality". Primary outcomes included the incidence of coronary artery disease, cerebrovascular disease, atrial fibrillation, and cardiovascular disease mortality among patients with thyroid cancer. Secondary outcomes included cardiovascular disease events among those with thyroid cancer that received or did not receive radioactive iodine or lenvatinib. Estimates were pooled using fixed- and random-effects meta-analysis.

Results

A total of 771,220 patients who underwent thyroidectomy in 15 studies were included. Risk for cerebrovascular disease (risk ratio [RR] 1.15 [95% confidence interval (CI) 1.10-1.21]) and atrial fibrillation [RR 1.59 (95% CI: 1.45-1.73)] were significantly increased. Risk for coronary artery disease was significantly increased [RR 1.12 (95% CI: 1.08-1.17)] in the common effect model. Cardiovascular disease mortality associated with thyroid cancer was not significant [RR 0.93 (95% CI: 0.59-1.45)]. Radioactive iodine had a neutral effect on cardiovascular disease [RR 1.00 (95% CI: 0.87-1.16)], and there was no beneficial nor harmful effect among different RAI doses.

Conclusions

Thyroid cancer was significantly associated with a higher risk for cerebrovascular disease and atrial fibrillation; however, the hazard risk was not different between patients with and without radioactive iodine treatment. Thyroid cancer treatment should be individualized considering the potential harms and benefits to cardiovascular health.

SUBMITTER: Tsai WH

PROVIDER: S-EPMC10020713 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Association between thyroid cancer and cardiovascular disease: A meta-analysis.

Tsai Wen-Hsuan WH Zeng Yi-Hong YH Lee Chun-Chuan CC Chien Ming-Nan MN Liu Sung-Chen SC Chien Kuo-Liong KL Cheng Shih-Ping SP Tseng Po-Jung PJ Tsai Ming-Chieh MC

Frontiers in cardiovascular medicine 20230303

<h4>Objective</h4>To determine the association between thyroid cancer and coronary artery disease, atrial fibrillation, cerebrovascular disease, and cardiovascular disease mortality.<h4>Methods</h4>The PubMed, Embase, and Cochrane Library databases were searched for eligible studies from inception to September 22, 2022. Keywords included "thyroid cancer", "atrial fibrillation", "coronary artery disease", "cerebrovascular disease", and "mortality". Primary outcomes included the incidence of coron ...[more]

PMID: 36937933

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Dataset Information

Association between thyroid cancer and cardiovascular disease: A meta-analysis.

Objective

Methods

Results

Conclusions

Publications

Association between thyroid cancer and cardiovascular disease: A meta-analysis.

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