Quantitative proteomics identified a novel invasion biomarker associated with EMT in pituitary adenomas.

ABSTRACT:

Background

Complete resection of invasive pituitary adenoma is usually difficult, resulting in a high recurrence rate. Therefore, it is needed to find potential diagnostic markers and therapeutic targets for invasive pituitary adenoma.

Methods

We collected samples from patients with invasive and non-invasive pituitary adenomas from Beijing Tiantan Hospital for protein extraction and quantitative analysis. We identified differential proteins (DEPs) by differential analysis of the two groups. The intersection of differential proteins related to invasion and epithelial-mesenchymal transition (EMT) in the GeneCards database was identified as EMT-DEPs. The protein network of EMT-DEPs was analyzed using the STRING database and Cytoscape software, and the hub EMT-DEPs were obtained

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC10020714 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature