Scatter Photocoagulation Does Not Reduce Macular Edema or Treatment Burden in Patients with Retinal Vein Occlusion: The RELATE Trial.

ABSTRACT:

Purpose

To determine whether scatter and grid laser photocoagulation (laser) adds benefit to ranibizumab injections in patients with macular edema from retinal vein occlusion (RVO) and to compare 0.5-mg with 2.0-mg ranibizumab.

Design

Randomized, double-masked, controlled clinical trial.

Participants

Thirty-nine patients with central RVO (CRVO) and 42 with branch RVO (BRVO).

Methods

Subjects were randomized to 0.5 mg or 2.0 mg ranibizumab every 4 weeks for 24 weeks and re-randomized to pro re nata ranibizumab plus laser or ranibizumab alone.

Main outcome measures

Mean change from baseline best-corrected visual acuity (BCVA) at week 24 for BCVA at weeks 48, 96, and 144 for second randomization.

Results

Mean improvement from baseline BCVA at week 24

SUBMITTER: Campochiaro PA 

PROVIDER: S-EPMC10020833 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature