The Risk of Cholesteatoma in Individuals With First-degree Relatives Surgically Treated for the Disease.

ABSTRACT:

Importance

Cholesteatoma in the middle ear is not regarded as a hereditary disease, but case reports of familial clustering exist in the literature, as well as observed familial cases in the clinical work. However, the knowledge regarding cholesteatoma as a hereditary disease is lacking in the literature.

Objective

To assess the risk of cholesteatoma in individuals with a first-degree relative surgically treated for the same disease.

Design, setting, and participants

In this nested case-control study in the Swedish population between 1987 and 2018 of first-time cholesteatoma surgery identified from the Swedish National Patient Register, 2 controls per case were randomly selected from the population register through incidence density sampling, and all first-degree rela

SUBMITTER: Bonnard A 

PROVIDER: S-EPMC10020932 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature